Colt Python The most in depth study of handgun deaths, showed that the magnum was the deadliest round. It was not responsible for the most deaths, but was the only round that on average took less than two shots to prove fatal.
Smith and Wesson model 627 snub nose 8 shot. in my opinion the best handgun to carry for back packing/hiking in the lower 48 states. If you add Grizzly ammunition to it, its a good Montana and Alaska handgun too for Brown (Grizzly) bear and Moose defense.