A tendency toward intuitive thinking helps explain the link between schizotypal traits and conspiracy beliefs
According to findings published in Applied Cognitive Psychology, a person’s preferred thinking style can increase their susceptibility to believing in ...
AI used to predict early symptoms of schizophrenia in relatives of patients: Researchers develop machine learning tool to analyze brain scans, identify risk for earlier diagnosis and treatment.
Researchers have taken a step forward in developing an artificial intelligence tool to predict schizophrenia by analyzing brain scans. The tool was used to analyze functional magnetic resonance images of 57 healthy first-degree relatives (siblings or children) of schizophrenia patients. It accurately identified the 14 individuals who scored highest on a self-reported schizotypal personality trait scale.
Increased risk of Parkinson's disease in patients with schizophrenia
A new study shows that patients with a schizophrenia spectrum disorder have an increased risk of Parkinson's disease later in life. The increased risk may be due to alterations in the brain's dopamine system caused by dopamine receptor antagonists or neurobiological effects of schizophrenia.
Large transporter protein linked to schizophrenia: Investigations of a cellular protein have uncovered a possible link with schizophrenia
Scientists have suspected mutations in a cellular cholesterol transport protein are associated with psychiatric disorders, but have found it difficult to prove this and to pinpoint how it happens. Now, researchers have provided evidence that mice with disrupted ABCA13 protein demonstrate a hallmark behavior of schizophrenia.
Gene pathway linked to schizophrenia identified through stem cell engineering
Using human-induced pluripotent stem cells engineered from a single family's blood samples, a gene signaling pathway linked to a higher risk for developing schizophrenia was discovered.
Psychology study uncovers new details about the cognitive underpinnings of belief in conspiracy theories
People who believe in conspiracy theories display a cognitive bias -- known as the jumping-to-conclusions bias -- that is commonly observed in ...
Translation-Focused Approaches to GPCR Drug Discovery for Cognitive Impairments Associated with Schizophrenia
There are no effective therapeutics for cognitive impairments associated with schizophrenia (CIAS), which includes deficits in executive functions (working memory and cognitive flexibility) and episodic memory. Compounds that have entered clinical trials are inadequate in terms of efficacy and/or tolerability, highlighting a clear translational bottleneck and a need for a cohesive preclinical drug development strategy. In this review we propose hippocampal–prefrontal-cortical (HPC–PFC)…
Immune responses during embryo development could increase risk of schizophrenia
Past research has often highlighted the effects that immune activation in pregnant women can have on the development of human embryos, for instance increasing the risk of a child developing psychiatric disorders later in life. The neural mechanisms underpinning these effects, however, remain largely unclear.
Long-acting antipsychotic therapy plus cognitive training show promise for schizophrenia: Patients who received the combination therapy had increased cognition and functioning
Scientists have found that the use of long-acting antipsychotic medication combined with the use of cognitive training in group settings led to improved cognition and increased productivity.
Computer model explains altered decision making in schizophrenia
Scientists have built a computer 'brain circuit', or artificial neural network, that mirrors human decision-making processes and sheds light on how circuits might be altered in psychiatric diseases.
Schizophrenia related to abnormal fatty metabolism in the brain
Researchers have discovered a deficiency in the brains of people with schizophrenia that could lead to the development of new drug therapies. A postmortem comparison revealed that schizophrenia was associated with lower than normal levels of S1P, a type of fatty molecule found in the white matter of the brain.
Whole genome sequencing reveals genetic structural secrets of schizophrenia
Scientists have conducted the largest-ever whole genome sequencing study of schizophrenia to provide a more complete picture of the role the human genome plays in this disease.
Researchers discover second type of schizophrenia
Penn Medicine researchers are the first to discover two distinct neuroanatomical subtypes of schizophrenia after analyzing the brain scans of over 300 patients. The first type showed lower widespread volumes of gray matter when compare to healthy controls, while the second type had volumes largely similar to normal brains. The findings, published Thursday in the journal Brain, suggest that, in the future, accounting for these differences could inform more personalized treatment options.
Engaging with schizophrenia: Experts argue for new approaches to treatment
A better understanding of the lived experience of people with schizophrenia would enable clinicians to help patients live with their condition, alongside treating symptoms with medication and psychotherapy, say experts.
Study finds that lack of oxygen during pregnancy can cause schizophrenia
Lack of oxygen during the period anticipating child birth, a condition that may affect children of pregnant women subjected to a high blood pressure disorder called pre-eclampsia, has been found to be a cause of schizophrenia. In an article published in Scientific Reports, researchers at Santa Casa de São Paulo Medical School (FCM-SCSP) in Brazil described how this phenomenon, called hypoxia, affects astrocytes, one of the most abundant types of brain cell.